- Sales & Marketing Consultant, Roxboro
- Scientific & Laboratory Equipment & Instruments, Roxboro
- Secondary Schools, Roxboro
- Security Alarm Systems - Home & Business, Roxboro
- Security Brokers & Dealers, Roxboro
- Security Control Systems & Monitoring, Roxboro - Polygraph, Lie Detector, CCTV, Fire Sensor Equipment, Etc
- Security Services, Roxboro
- Senior Citizens Housing, Roxboro
- Service Establishment Supplies & Equipment, Roxboro
- Sheet Metal Contractors, Roxboro - Sheet Metal Fabrication
- Sheet Metal Fabricators & Ductwork Contractors, Roxboro
- Shopping & Shopping Services, Roxboro
- Siding Contractors, Roxboro - Vinyl Siding, Wood, Metal & Aluminum Siding Contractors - Installation & Repair
- Small Appliances, Roxboro
- Snacks & Desserts, Roxboro
- Snow Removal Services, Roxboro - Snow Plow Service
- Social Services & Welfare, Roxboro
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- Societies & Foundation Associations, Roxboro
- Special Interest Schools Or Instruction, Roxboro
- Speciality Food Stores, Roxboro
- Specialty Animal Services, Roxboro
- Specialty Goods Storage, Roxboro
- Specialty Stores, Roxboro
- Speech & Hearing Specialists, Roxboro
- Sporting & Recreational Camps, Roxboro
- Sporting Goods Stores, Roxboro
- Sports Promoters & Managers, Roxboro
- Sports Promotions & Special Events, Roxboro
- Sprinkler Alarm Systems, Roxboro - Fire Sprinkler Systems
- Stenciling Supplies, Roxboro
- Stock & Bond Brokers & Dealers, Roxboro
- Stocks & Bond Brokers, Roxboro
- Store & Retail Fixtures & Display Manufacturers, Roxboro
- Swimming Pools, Roxboro
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